Resource Center
A Helpful Suite of Clinical Resources for Your Practice
Are you managing patients with cirrhosis at risk for overt HE? Access peer-guided videos, clinical tools, and comprehensive guides to help your patients throughout their journey.
PEER PERSPECTIVES
In this video series, Punam Punja, PA-C, is “on call” to offer her clinical perspectives on common questions APPs have about HE, including symptom monitoring and patient management.
Video
4 mins
Episode 1: Screening for Decompensation
Progression of liver disease to cirrhosis can be easy to miss. See how Punam monitors for signs and symptoms of cirrhosis and when she begins screening for decompensating events, like HE.
CIRRHOSIS AND DEVELOPMENT OF OVERT HE
Utilize this interactive guide to explore the pathophysiology that drives HE, recognize the symptoms of overt HE, and learn about guideline-based care.
Use this resource with helpful tips and considerations to aid in assessment of HE in patients with cirrhosis, including quick-hit questions to guide both patient and caregiver discussions.
FOR YOUR PATIENTS
Access this patient-friendly resource to review the key risks associated with cirrhosis progression, with clear visuals to share with your patients about signs of decompensation to watch out for, including HE.
Share this resource with patients concerned about liver disease to empower them to be more involved in routine monitoring and testing, including the use of FIB-4 to gauge their risk of fibrosis and cirrhosis.
A checklist for patients or caregivers to record common symptoms of hepatic encephalopathy. Share with your patients and/or caregivers prior to or at their visit to help them identify when to access immediate care or to facilitate a more productive discussion about their symptoms at their next appointment.
PEER PERSPECTIVES
In this video series, Punam Punja, PA-C, is “on call” to offer her clinical perspectives on common questions APPs have about HE, including symptom monitoring and patient management.
Video
4 mins
Episode 2: Conversations with Patients and Caregivers
Patients with cirrhosis, as well as their caregivers, should be educated on the risk of developing HE. Watch how Punam explains HE in simple terms to her patients and how she includes caregiver insights when screening for HE.
Video
4 mins
Episode 3: Guideline-Directed Care
Optimal care for patients at risk of HE should include guideline-recommended strategies. Follow along with Punam as she shares how HE management guidelines have evolved and her approach to implementing them in clinical practice.
Video
2 mins
Episode 4: The Importance of Medication Adherence in HE
It can be difficult for patients with HE and their caregivers to stay on top of medications that decrease the risk of future HE episodes. See how Punam helps ensure her patients follow their management plan and remain adherent to their medication regimens, with advice on counseling and monitoring for breakthrough symptoms.
HE MANAGEMENT & CARE GUIDELINES
See the 2026 ACG Clinical Guideline strategies and approaches for patients with suspected HE, including best practices from evaluation to discharge.
Review recommendations from the 2026 ACG Clinical Guideline for the prevention of overt HE recurrence, including the use of XIFAXAN and the importance of proper nutrition and exercise
Information on identifying patients at risk for overt HE recurrence, how to act with guideline-based care, and reducing the risk of recurrence with XIFAXAN.
CLINICAL PRACTICE
Watch fellow clinicians discuss clinical insights in the management of adult patients with overt HE.
Video
13 mins
The Role of NPs and PAs in Supporting HE Patient Care
Hosted by Christina J. Hanson, FNP
Featuring Mikhail Alper, PA-C
Hear from fellow NPs and PAs about distinct opportunities you may have to support the care of adults with overt hepatic encephalopathy (HE) throughout their journeys.
Video
3 mins
The Importance of Recognizing
Hepatic Encephalopathy in
Your Cirrhosis Patients
Video
22 mins
Management of Overt HE
Hosted by Christina J. Hanson, FNP
Featuring Sharon Magalona, FNP-BC
Tune in to an overview about overt hepatic encephalopathy (HE) and learn about guideline recommendations and management for the reduction in risk of overt HE recurrence in adults.
Video
3 mins
Assessing for HE in Patients With Cirrhosis
Video
5 mins
Guideline Recommendation for Adults at Risk of Overt Hepatic Encephalopathy Recurrence
Video
10 mins
Recognizing and Managing Overt HE Patients in Long-term Care Settings
Featuring Corrie T. Berk, DNP, MBA
Follow along with your peer as she discusses what you can do to help manage overt HE and hospitalizations in patients with cirrhosis in long-term care settings.
PATIENT CASE STUDIES
Consult these peer-guided patient case videos to help identify adult patients for whom XIFAXAN may be an appropriate therapy.
Video
8 mins
Management Considerations After an Overt HE Episode
Featuring Rebecca McCollaum, NP
Follow along on the journey of Susan, who requires improved management after being hospitalize due to a recurrent overt HE episode.
Video
9 mins
Reducing the Risk of Recurrence Following an Overt HE Hospitalization
Featuring Samantha Ramirez, NP-C
Follow along on the journey of Carlos, who was recently hospitalized for an overt HE episode and followed up with his primary care provider due to another episode.
Download and share this handout with your peers to direct them to IBS-D and overt HE patient case studies presented by practicing APPs.
Test your HE clinical acumen! Apply best practices for a hypothetical patient through proper testing, diagnosis, and management of overt HE.
Reduction of Overt HE Recurrence Risk Using Rifaximin: Real-World Evidence and Perspectives
Features an overview of overt HE management and clinical highlights from Arun Jesudian, MD, about real-world evidence data and Corrie Berk, DNP, MBA, about the importance of transitions of care in patients with HE.
FOR YOUR PATIENTS
Video
10 mins
Managing Overt HE With XIFAXAN
Featuring Arun Jesudian, MD
Share this video aimed at educating patients and caregivers about overt HE management, including the use of XIFAXAN to reduce the risk of overt HE recurrence.
Share with your patients to provide a brief overview of reducing the risk of overt HE recurrence with XIFAXAN, including dosing and savings program details.
Before discharge following an overt HE episode, give this resource to your patients and their caregivers to help ensure they are informed about the condition and next steps in management.
XIFAXAN Savings Card
Most eligible* patients with commercial insurance and coverage for XIFAXAN may pay as little as $0 for their XIFAXAN prescription. Maximum benefits and other restrictions apply.
FOR YOUR PRACTICE
Highlights XIFAXAN efficacy and safety data, dosing, and the steps to complete a prior authorization. Share this guide with colleagues who may less frequently manage adult patients at risk of overt HE recurrence.
Utilize this guide to review best practices in counseling patients on management of overt HE, highlighting the use of XIFAXAN, as well as ensuring proper nutrition and ongoing symptom monitoring.
Overview of the importance of medication adherence for patients receiving long-term therapy. Refer to this guide for helpful information when prescribing XIFAXAN for the reduction in risk of overt HE recurrence in adults.
Review the recommended XIFAXAN dosing for the reduction in risk of overt HE recurrence in adults.
Core information on XIFAXAN for the reduction in risk of overt HE recurrence in adults. Provides an overview of HE, including screening criteria and the impact of overt HE on cognition and patients' health. Efficacy and safety data for XIFAXAN, recommended dosing, and information on insurance coverage are also included.
Video
7 mins
Ensure XIFAXAN Prescriptions Are Written Correctly
Watch as Clinical Pharmacy Specialist Ralph Riello, PharmD, discusses best practices to help with XIFAXAN prior authorization.
Step-by-step guide for completing prior authorization (PA) requirements for patients prescribed XIFAXAN, including common reasons for PA denials and guidance for Letters of Medical Necessity when needed. Download for guidance on PA requests, as well as information on electronic submissions with CoverMyMeds.
A tier exemption request to reduce the cost-share of a medication. Follows submission of a prior authorization or utilization management request.
A standard form for a patient-specific letter of medical necessity to explain your clinical decision-making in choosing a therapy.
Learn how an Extra Help/Low-Income Subsidy (LIS) benefits program may help your patients start and stay on treatment. Identify the two ways patients can receive Extra Help/LIS benefits, and discover how you can help patients apply for the program.
*Patient is not eligible if he/she participates in or seeks reimbursement or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage, such as Medicaid, Medicare, Medigap, VA, DOD, TRICARE, or any similar federal or state health care program (each a Government Program), or where prohibited by law. Patient must be enrolled in, and must seek reimbursement from or submit a claim for reimbursement to, a commercial insurance plan. Offer excludes full cash-paying patients. Maximum benefits and other restrictions apply. Visit https://xifaxan.copaysavingsprogram.com/ or call 1-866-XIFAXAN for full eligibility criteria, terms and conditions.
PEER PERSPECTIVES
In this video series, Punam Punja, PA-C, is “on call” to offer her clinical perspectives on common questions APPs have about HE, including symptom monitoring and patient management.
Video
4 mins
Episode 1: Screening for Decompensation
Progression of liver disease to cirrhosis can be easy to miss. See how Punam monitors for signs and symptoms of cirrhosis and when she begins screening for decompensating events, like HE.
CIRRHOSIS AND DEVELOPMENT OF OVERT HE
PDFUtilize this interactive guide to explore the pathophysiology that drives HE, recognize the symptoms of overt HE, and learn about guideline-based care.
Use this resource with helpful tips and considerations to aid in assessment of HE in patients with cirrhosis, including quick-hit questions to guide both patient and caregiver discussions.
FOR YOUR PATIENTS
Access this patient-friendly resource to review the key risks associated with cirrhosis progression, with clear visuals to share with your patients about signs of decompensation to watch out for, including HE.
Share this resource with patients concerned about liver disease to empower them to be more involved in routine monitoring and testing, including the use of FIB-4 to gauge their risk of fibrosis and cirrhosis.
A checklist for patients or caregivers to record common symptoms of hepatic encephalopathy. Share with your patients and/or caregivers prior to or at their visit to help them identify when to access immediate care or to facilitate a more productive discussion about their symptoms at their next appointment.
PEER PERSPECTIVES
In this video series, Punam Punja, PA-C, is “on call” to offer her clinical perspectives on common questions APPs have about HE, including symptom monitoring and patient management.
Video
4 mins
Episode 2: Conversations with Patients and Caregivers
Patients with cirrhosis, as well as their caregivers, should be educated on the risk of developing HE. Watch how Punam explains HE in simple terms to her patients and how she includes caregiver insights when screening for HE.
Video
4 mins
Episode 3: Guideline-Directed Care
Optimal care for patients at risk of HE should include guideline-recommended strategies. Follow along with Punam as she shares how HE management guidelines have evolved and her approach to implementing them in clinical practice.
Video
2 mins
Episode 4: The Importance of Medication Adherence in HE
It can be difficult for patients with HE and their caregivers to stay on top of medications that decrease the risk of future HE episodes. See how Punam helps ensure her patients follow their management plan and remain adherent to their medication regimens, with advice on counseling and monitoring for breakthrough symptoms.
HE MANAGEMENT & CARE GUIDELINES
See the 2026 ACG Clinical Guideline strategies and approaches for patients with suspected HE, including best practices from evaluation to discharge.
Review recommendations from the 2026 ACG Clinical Guideline for the prevention of overt HE recurrence, including the use of XIFAXAN and the importance of proper nutrition and exercise
Information on identifying patients at risk for overt HE recurrence, how to act with guideline-based care, and reducing the risk of recurrence with XIFAXAN.
CLINICAL PRACTICE
Watch fellow clinicians discuss clinical insights in the management of adult patients with overt HE.
Video
13 mins
The Role of NPs and PAs in Supporting HE Patient Care
Hosted by Christina J. Hanson, FNP
Featuring Mikhail Alper, PA-C
Hear from fellow NPs and PAs about distinct opportunities you may have to support the care of adults with overt hepatic encephalopathy (HE) throughout their journeys.
Download Podcast AudioVideo
3 mins
The Importance of Recognizing
Hepatic Encephalopathy in
Your Cirrhosis Patients
Video
22 mins
Management of Overt HE
Hosted by Christina J. Hanson, FNP
Featuring Sharon Magalona, FNP-BC
Tune in to an overview about overt hepatic encephalopathy (HE) and learn about guideline recommendations and management for the reduction in risk of overt HE recurrence in adults.
Video
3 mins
Assessing for HE in Patients With Cirrhosis
Video
5 mins
Guideline Recommendation for Adults at Risk of Overt Hepatic Encephalopathy Recurrence
Video
10 mins
Recognizing and Managing Overt HE Patients in Long-term Care Settings
Featuring Corrie T. Berk, DNP, MBA
Follow along with your peer as she discusses what you can do to help manage overt HE and hospitalizations in patients with cirrhosis in long-term care settings.
PATIENT CASE STUDIES
Consult these peer-guided patient case videos to help identify adult patients for whom XIFAXAN may be an appropriate therapy.
Video
8 mins
Management Considerations After an Overt HE Episode
Featuring Rebecca McCollaum, NP
Follow along on the journey of Susan, who requires improved management after being hospitalize due to a recurrent overt HE episode.
Video
9 mins
Reducing the Risk of Recurrence Following an Overt HE Hospitalization
Featuring Samantha Ramirez, NP-C
Follow along on the journey of Carlos, who was recently hospitalized for an overt HE episode and followed up with his primary care provider due to another episode.
Download and share this handout with your peers to direct them to IBS-D and overt HE patient case studies presented by practicing APPs.
Test your HE clinical acumen! Apply best practices for a hypothetical patient through proper testing, diagnosis, and management of overt HE.
Reduction of Overt HE Recurrence Risk Using Rifaximin: Real-World Evidence and Perspectives
Features an overview of overt HE management and clinical highlights from Arun Jesudian, MD, about real-world evidence data and Corrie Berk, DNP, MBA, about the importance of transitions of care in patients with HE.
FOR YOUR PATIENTS
Video
10 mins
Managing Overt HE With XIFAXAN
Featuring Arun Jesudian, MD
Share this video aimed at educating patients and caregivers about overt HE management, including the use of XIFAXAN to reduce the risk of overt HE recurrence.
Share with your patients to provide a brief overview of reducing the risk of overt HE recurrence with XIFAXAN, including dosing and savings program details.
Before discharge following an overt HE episode, give this resource to your patients and their caregivers to help ensure they are informed about the condition and next steps in management.
LinkXIFAXAN Savings Card
Most eligible* patients with commercial insurance and coverage for XIFAXAN may pay as little as $0 for their XIFAXAN prescription. Maximum benefits and other restrictions apply.
FOR YOUR PRACTICE
Highlights XIFAXAN efficacy and safety data, dosing, and the steps to complete a prior authorization. Share this guide with colleagues who may less frequently manage adult patients at risk of overt HE recurrence.
Utilize this guide to review best practices in counseling patients on management of overt HE, highlighting the use of XIFAXAN, as well as ensuring proper nutrition and ongoing symptom monitoring.
Overview of the importance of medication adherence for patients receiving long-term therapy. Refer to this guide for helpful information when prescribing XIFAXAN for the reduction in risk of overt HE recurrence in adults.
Review the recommended XIFAXAN dosing for the reduction in risk of overt HE recurrence in adults.
Core information on XIFAXAN for the reduction in risk of overt HE recurrence in adults. Provides an overview of HE, including screening criteria and the impact of overt HE on cognition and patients' health. Efficacy and safety data for XIFAXAN, recommended dosing, and information on insurance coverage are also included.
Video
7 mins
Ensure XIFAXAN Prescriptions Are Written Correctly
Watch as Clinical Pharmacy Specialist Ralph Riello, PharmD, discusses best practices to help with XIFAXAN prior authorization.
Step-by-step guide for completing prior authorization (PA) requirements for patients prescribed XIFAXAN, including common reasons for PA denials and guidance for Letters of Medical Necessity when needed. Download for guidance on PA requests, as well as information on electronic submissions with CoverMyMeds.
A tier exemption request to reduce the cost-share of a medication. Follows submission of a prior authorization or utilization management request.
A standard form for a patient-specific letter of medical necessity to explain your clinical decision-making in choosing a therapy.
Learn how an Extra Help/Low-Income Subsidy (LIS) benefits program may help your patients start and stay on treatment. Identify the two ways patients can receive Extra Help/LIS benefits, and discover how you can help patients apply for the program.
*Patient is not eligible if he/she participates in or seeks reimbursement or submits a claim for reimbursement to any federal or state healthcare program with prescription drug coverage, such as Medicaid, Medicare, Medigap, VA, DOD, TRICARE, or any similar federal or state health care program (each a Government Program), or where prohibited by law. Patient must be enrolled in, and must seek reimbursement from or submit a claim for reimbursement to, a commercial insurance plan. Offer excludes full cash-paying patients. Maximum benefits and other restrictions apply. Visit https://xifaxan.copaysavingsprogram.com/ or call 1-866-XIFAXAN for full eligibility criteria, terms and conditions.
